Active ingredient: Yohimbine hydrochloride
Type: α2-adrenergic receptor antagonist
Form: Oral (pills)
Description
Yohimbine is an indolalkylamine alkaloid mainly used as a fat burner. However, it is also an effective treatment for erectile dysfunction and possesses mydriatic properties. The component belongs to the class of alkaloids with alpha-2-adrenergic blocking activity. It affects presynaptic alpha-2 adrenergic receptors, blocking them.
According to the action on peripheral blood vessels, the component has a similar effect of reserpine, though it is weaker and causes short duration. The main impact of Yohimbine’s peripheral autonomic nervous system is aimed at increasing parasympathetic (cholinergic) and decreasing sympathetic (adrenergic) activity. If we consider male sexual performance, erection is linked to cholinergic activity and alpha-2 adrenergic blockade. As a result, the effect is increased penile inflow and decreased penile outflow.
Besides, Yohimbine also has an effect on mood and may increase anxiety sometimes. Note that such actions have not been adequately studied or related to dosage. However, they are noticed when the treatment dose is high.
Yohimbine has a mild antidiuretic action. It is likely to appear due to stimulation of the hypothalamic center and the release of posterior pituitary hormone.
As for the cardiovascular system, no significant influence of Yohimbine is reported. It also does not have effects mediated by (beta)-adrenergic receptors. The component does not affect blood pressure significantly. If any impact is observed, it lowers it. Yet, no studies have proved any connection between Yohimbine dosage and blood pressure surges.
Mechanism of Action
Yohimbine is a presynaptic alpha 2-adrenergic blocking agent. However, note that the exact mechanism for its use in impotence has not been fully elucidated. Although no clear evidence is provided the component exerts its beneficial effect on erectile ability. The effect is achieved through the blockade of central alpha 2-adrenergic receptors. By acting on them, Yohimbine causes an increase in sympathetic drive secondary and norepinephrine release. The ingredient also affects the brain’s noradrenergic nuclei causing an increase in the firing rate of cells. Note that Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. Additional beneficial effects may also include other neurotransmitters, such as serotonin and dopamine, as well as cholinergic receptors.
Purpose of Use
The product is often used during cutting cycles. Due to its alpha 2-adrenergic blocking properties, the component has a pronounced lipolytic effect. When beta receptors are excited by adrenaline (or its mimetics), fat is destroyed. The opposite effect is observed when alpha receptors are excited: adrenaline release is inhibited and fat in fat depots is accumulated. By blocking alpha receptors, the component allows fat to break down freely with the release of energy. Thus, the product is often used as a fat burner in a blend with Clenbuterol due to its pronounced synergic effects.
There are additional reasons that dictate the need to block alpha 2-adrenergic receptors. Component intake allows you to reduce blood pressure and increase blood flow in adipose tissue, thereby accelerating the transport of fatty acids to the destruction site. The difficulty of burning fat in some zones is explained precisely by the large number of alpha2-adrenergic receptors. Yohimbine can help to remove fat deposits in the most problematic places more effectively.
Yohimbinos is a unique supplement that has a high concentration of the regarded active component.
Dosage
A safe dose of Yohimbine is up to 20 mg.
Usually, the dose selection of pills starts from 2.5–5 mg.
Effects
Yohimbine tablets have the following beneficial properties on the body:
- Has an aphrodisiac activity, causing male enhancement.
- Stimulates libido and enhances sexual arousal, being a potency stimulant.
- Increases the blood supply to the cavernous bodies.
- Improves the psycho-emotional background and sexual health. Pills help eliminate feelings of discomfort, insecurity, stiffness, and fear during sex.
- Has an antidiuretic effect.
- Mobilizes fatty acids from subcutaneous adipose tissue due to which it can be used as a fat burner.
- Increases motor activity and physical performance due to which it’s widely used during pre-workout periods or fitness workouts to improve endurance and strength.
- Increases blood pressure (due to stimulation of the vasomotor center) in small doses.
- Reduces blood pressure (due to a-adrenergic blocking action) in large doses.
- Weakens the action of serotonin, which causes depression and nervousness if the body produces insufficient amounts of it.
Side Effects
- Fluctuations in blood pressure and tachycardia (due to a stimulating effect on the heart).
- Agitation.
- Insomnia or drowsiness.
- Headache.
- Dizziness.
- Redness of the skin (due to vasodilation).
Profile
Half-life: 6 hours.
Frequency of intake: 1–2 times a day.
Contraindications
The risk of side effects increases when combined with other stimulants (complex supplements).
How to Store?
- Keep away from children.
- Keep in a cool, dry place, away from direct sunlight.
- Store at room temperature.
- Do not use it after the expiry date.
Tolerance
Some people may develop tolerance to Yohimbine. It means that an increase in the dose is required over time to achieve the same effect. This process is associated with several mechanisms:
- Desensitization of receptors. As the component is exposed for a long time to alpha-2-adrenergic receptors located on the surface of fat cells, desensitization of these receptors may occur. This means that they become less sensitive to the effects of Yohimbine, and a bigger portion of an active component is required to achieve the desired effect.
- Reduced effectiveness: At the beginning of use, the supplement may have a more pronounced effect on fat burning and metabolism. However, over time, this effect may decrease, and the product becomes less effective.
To prevent or slow down the development of tolerance to Yohimbine, the following strategies can be used:
- Cyclic use. Many people use the supplement in cycles, with breaks in between. For example, two weeks of use followed by a four-week break. This can help maintain the sensitivity of the receptors.
- Avoiding long-term use. Yohimbine is best used in short-term cycles without the need to exceed the recommended doses.
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FAQ
Which is better, Yohimbe or Yohimbine?
Practically, these are the same structures. Yohimbine is one of the several indole alkaloids found in the Yohimbe tree’s bark.
When should I take the supplement?
A minimum dosage of 2.5 mg Yohimbine is the first step of supplement consumption. If you do not feel severe side effects, add another 2.5 mg every subsequent day. The usual daily dosage is 10-15 mg to 20 mg maximum. Divide the intake by 2 times, but do not use the dietary supplement in the afternoon due to hyperstimulation of the nervous system.
Is Yohimbine like Viagra?
Yes, the supplement causes a similar effect, improving erectile function and raising libido.
What not to mix Yohimbinos with?
Note that it’s advisable to take pills on an empty stomach. It’s advisable to avoid using alcohol during the treatment course.
What foods to avoid with Yohimbine?
When consuming the supplement, avoid eating foods that contain tyramine. Common foods that contain tyramine include nuts, chocolate, cheese, aged or smoked meats, sauerkraut, and yeast. Beverages such as beer and red wine also contain tyramine.
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